-1.png?width=2000&height=465&name=Untitled%20design%20(18)-1.png)
Upperton Insights
A leading Contract, Development, and Manufacturing Organisation, this podcast highlights scientists developing the future of medicine. Listen along to hear from our experts, and to learn about the manufacturing of modern medicine.
At Upperton, our defining traits lie in our ability to problem solve and our dedication to excellence. We support biotechs with their drug development needs from pre-clinical to late phase and commercial manufacture.
Our flexibility ensures that we can problem-solve, meet timescales and deliver solutions that meet patient targets.
All Episodes
Scaling Up Oral Solid Dose Manufacturing For Late Phase Success
<p>Join Upperton for an in-depth session examining how strategic CDMO partnerships can accelerate late-phase development whilst ensuring quality and compliance. </p> <p>Led by Dipak Gordhan and Nathan Collingwood, this episode will explore process scale-up considerations, regulatory requirements, and how integrated development and manufacturing capabilities support the transition from clinical to commercial supply. </p> <p><br></p>The Formulation and Delivery of Spray Dried Biologics for Injectable Dosage Forms
<p>Injectable biologics are the backbone of modern therapeutics, but as molecules become more complex and doses increase, formulation challenges multiply. In this fireside chat, we’ll explore how spray drying is enabling high-concentration injectable biologics and encapsulated systems that improve stability, reduce viscosity, and enhance patient experience.</p> <p>We’ll begin by looking at the fundamentals of spray drying and why it’s emerging as a powerful tool for injectable formulations. Then, we’ll dive into the unique challenges of high-concentration biologics and how spray drying can help create stable, concentrated powders that reconstitute easily for injection.</p> <p>Next, we’ll explore encapsulation strategies for biologics. How can spray drying be used to create protective matrices or controlled-release particles for injectable delivery?</p> <p>Finally, we’ll cover testing and characterization from reconstitution performance and particle morphology to stability studies and potency assays, ensuring these advanced formulations meet stringent quality and regulatory requirements.</p> <p></p>Formulation and Delivery of Spray Dried Biologics for Oral Dosage Forms
<p>In this fireside chat, we’ll start by unpacking the fundamentals of pharmaceutical spray drying – what it is, how it works, and why it’s such a powerful tool in drug product development. From there, we’ll dive into the different types of oral dosage forms, like tablets and capsules, and explore how they fit into the world of biologics.</p> <p>Next, we’ll tackle the big question: what does it take to spray-dry biologics? We’ll talk through the unique challenges this process presents and highlight the opportunities it opens up for innovation. Finally, we’ll look at how these spray-dried biologics are tested and characterized to ensure quality, safety, and efficacy.</p> <p></p>Spray Dried Biologics For Nasal Dosage Forms
<p>With over 30 years experience in spray drying expertise, our founder Dr Richard Johnson and Senior Development Scientist II, Lara Penn, discuss spray dried biologics for nasal dosage forms.</p>